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Shortly after 10.10pm on Friday 29 January 2021, police were called to reports of a collision between a grey Smart ForFour and a cyclist on Chester Road at the junction with Sydney Street.
Emergency services attended and the cyclist - a 35-year-old woman - was taken to hospital with serious head injuries where she remains in a critical condition.
The driver of the car remained at the scene to speak with officers and no arrests have been made.
Enquiries are ongoing.
Police Sergeant Matt Waggett, of GMP's Serious Collision Investigation Unit, said: "A woman has been left fighting for her life as a result of this collision and we're doing everything we can to piece together the circumstances that led to it occurring.
"Our thoughts are very much with the woman and her family as our enquiries continue and I'd urge any witnesses or anyone with any information to get in touch as soon as possible."
Anyone with information should call GMP's Serious Collision Investigation Unit on 0161 856 4741 quoting incident number 3006 of 30/01/2021, or the independent charity Crimestoppers, anonymously, on 0800 555 111.