Officers were called around 6.50am today (Sunday 4 April) to a report of a collision at the junction of Clayton Street and Ashton New Road, Manchester.
Emergency services attended and enquiries established a blue Seat Ibiza and pedestrian had been in collision.
The pedestrian - a 46-year-old man was taken to hospital but despite the best efforts of medical staff he was sadly pronounced dead a short while later.
The driver of the Seat Ibiza remained at the scene to assist police with enquiries.
No arrests have been made and enquiries are on-going.
Sergeant Matthew Waggett of GMP's Serious Collision Investigation Unit, said: "First and foremost, our thoughts are very much with family and loved ones of the man who has sadly died this morning. Enquiries are currently ongoing to locate his next of kin.
"We appealing to anyone who may have been in the area at the time of this collision to come forward and speak with police. We're particularly keen to speak to anyone who may have witnessed the collision or is in possession of dash-cam footage from the area at the time."
Anyone with information should contact GMP's Serious Collision Investigation Unit on 0161 856 4741 quoting log 656 of 04/04/21. Alternatively, details can be passed on anonymously via the independent charity Crimestoppers on 0800 555 111.