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A short time after 1:30am on Saturday 7 August 2021, police were called to a report of a collision on Edge Lane, Droylsden.
Emergency services attended and established a Yamaha motorbike had collided with a Polo VW car.
Two men, aged 22 and 23, sustained serious injuries and both were taken to hospital. The 22-year-old man remains in a stable condition, however the 23-year-old man has since sadly died from his injuries, despite the best work of hospital staff.
No arrests have been made and enquiries are ongoing.
Police Sergeant Neil Pennington of GMP's Serious Collision Investigation Unit, said: "This is a tragic incident in which a man has sadly lost his life. Our thoughts are with his family at this incredibly distressing time and we wish a full recovery for the 22-year-old who is still in hospital.
"This collision happened in a residential area, so we are hopeful that people will have witnessed the collision and may have dash cam footage or CCTV footage of the incident.
"If you have any information at all about this collision please contact police as soon as possible."
Anyone with information should contact Serious Collision Investigation Unit on 0161 856 4741 quoting incident number 298 of 07/08/2021.
Reports can also be made anonymously via Crimestoppers on 0800 555 111.