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At around 5.30pm on Wednesday 1 September police were called to reports of a collision on Talbot Road in Hyde.
Emergency services attended and enquiries established a Toyota Rav4 had been travelling in an easterly direction along Talbot Road towards the junction of Acresfield Road.
At the same time, a 12-year-old boy was riding a scooter in the opposite direction along Talbot Rod when both he and the Toyota were involved in a collision with one another.
The boy was taken to hospital with serious injuries to his head and chest. He remains there in a life threatening condition.
No arrests have been made and enquiries are ongoing.
Officers are looking to speak to anyone who may have witnessed the collision or has information or dash-cam footage that could assist their investigation.
Anyone with information should contact police on 0161 856 4741, quoting incident number 2372.
Alternatively details can be passed via our LiveChat function at www.gmp.police.uk or calls can be made anonymously to the independent charity Crimestoppers on 0800 555 111.