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Officers were called just before 7.30pm on Wednesday 1 September 2021 to a report of a collision on Droylsden Road, Audenshaw.
Emergency services attended and enquiries established a 10-year-old boy on a bike had been involved in a collision with a tram.
The young boy was taken to hospital by air ambulance with a serious head injury.
He remains in hospital in a life threatening condition.
Enquiries are ongoing and no arrests have been made.
Police Sergeant Andrew Page of GMP's Serious Collision Investigation Unit, said: "Our thoughts are currently with the young boy who remains in hospital receiving urgent medical attention. Our main priority at this stage is establishing the full circumstances surrounding this collision so we can provide his family with the answers they need.
"This collision occurred early evening on a relatively busy road so we're confident there are people who may have witnessed the collision or be holding information or footage that could greatly assist our enquiries.
"We would urge anyone who thinks they be able to assist to get in touch as a matter of urgency."
Anyone with information should contact GMP's Serious Collision Investigation Unit on 0161 856 4741 or 101 quoting incident 2747 of 01/09/21.
Alternatively, details can be passed via our LiveChat function at www.gmp.police.uk or via the independent charity Crimestoppers on 0800 555 111.