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Officers were called by colleagues at NWAS around 10.15am today (Monday 24 May) to a report of an injured male on Yew Tree Road, Manchester.
Officers attended and enquiries established a man in his 20s had been stabbed in the head.
The man was taken to hospital. His injuries are now not believed to be life-threatening.
Two men, aged 22 and 32, have been arrested on suspicion of section 18 assault. They remain remains in custody for questioning.
Extensive enquiries are ongoing and scene remains in place.
Detective Inspector Pete Morley of GMP's City of Manchester division, said: "This was a serious assault that has left one man in hospital. Our thoughts are with him as he receives urgent medical attention.
"Our enquiries are in their initial stages but we do believe this to have been an isolated incident with no wider threat to the public. We currently have two males detained and in custody for questioning but we would appeal for anyone with information to come forward and assist us with our investigation."
Anyone with information should contact police on 0161 856 6409 quoting incident 761 of 24/05/21. Alternatively, details can be passed on anonymously via the independent charity Crimestoppers on 0800 555 111.