At 9.30pm on Friday 4 February 2022, police were called by the ambulance service responding to a report of a stabbing on Cheetham Hill Road, Dukinfield.
Emergency services attended and a man, believed to be 20, was sadly pronounced dead at the scene. His next of kin has been informed.
Four teenage boys, two aged 16 and two aged 17, have been arrested on suspicion of murder. They remain in police custody for questioning.
Detective Superintendent Ian Crewe of GMP's Major Incident Team said: "Our thoughts are with the victim's loved ones - specialist officers are liaising with them and caring for them.
"We have four suspects in custody but our investigation is very much ongoing and I would appeal to anyone with information or dash cam footage from the main or surrounding roads at around 9.30pm last night to contact us.
"We have deployed extra officers to the area to support the investigation team and the community and I want members of the public to know that they can approach and talk to them.
"The force is working with partner agencies to fight, prevent and reduce knife crime so I'll also use this opportunity to encourage anyone who knows or suspects someone is carrying a weapon to report it before it's too late."
Anyone with information should contact police quoting 2866 04/02/22 via 0161 856 3400 or gmp.police.uk. Alternatively, the independent charity - Crimestoppers, anonymously, on 0800 555 111.