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Police were called at 1.10am today (Friday 6 August 2021) to Redesmere Close, Droylsden to a report of a stabbing.
Emergency services attended and enquiries established a 47-year-old man had been stabbed inside a property.
He was taken to hospital in a critical condition where, despite the best efforts of medical staff, he was sadly pronounced dead a short while later.
A 21-year-old man has been arrested on suspicion of murder. He remains in custody for questioning.
No other injuries have been reported and enquiries are ongoing.
Detective Chief Inspector Stuart Wilkinson of GMP's Major Incident Team, said:
"A man has very sadly lost his life in the early hours of this morning and we've launched a full investigation to piece together the full circumstances surrounding his death.
"Our main priority at this stage is ensuring his next of kin are located and given the full support that they need as they begin to come to terms with this devastating news.
"We currently have one man in custody for questioning but our enquiries will continue and I would encourage anyone who may be holding any information that could assist us to get in touch as a matter of urgency. Even the smallest bit of information could prove vital to our investigation."
Anyone with information should contact police on 0161 856 9908 or 101 quoting incident 134 of 06/08/21. Alternatively, details can be passed by our LiveChat function at www.gmp.police.uk or via the independent charity Crimestoppers on 0800 555 111.