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At around 9:30am on 6 August, police were called to Edge Lane, Droylsden to a report of a collision.
Emergency services attended and established a car had collided with a pedestrian.
A 78-year-old man received serious injuries and was taken to hospital. He remains in a serious condition.
The driver of the car, a 36-year-old man, was arrested at the scene on suspicion of causing serious injury by dangerous driving and drug driving. He has since been released under investigation.
Less than 24 hours later, at around 1:30am this morning (7 August) police were called to a report of a further collision on Edge Lane.
Emergency services attended and established a motorbike had collided with a car.
Two men, aged 22 and 23, sustained serious injuries and both were taken to hospital. One of the men is in a life-threatening condition.
Police Sergeant Andrew Page of Greater Manchester's Serious Collision Investigation Unit said: "Two very serious incidents have taken place on this road in 24 hours, leaving three men with serious injuries, one of which is life threatening. Our specialist officers are supporting the families of the men affected by these incidents.
"We're now investigating the events that led to these collisions, and the community will see an increased presence in the area. There will be a staffed ANPR car and extra traffic patrols present and monitoring, while our investigations continue.
"If you were present in the area at the times of these collisions, have dash-cam footage, or any other information, please contact police on 0161 856 4741, alternatively report to us online at www.gmp.police.uk, using our online reporting or Live Chat functions."
"Please do take caution when driving, particularly as we experience changing weather conditions. Further advice on road safety can be found at think.gov.uk."
Reports can also be made anonymously via Crimestoppers on 0800 555 111.