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Police were called around 7.45pm on Thursday 17 December to a report of a pedestrian walking along the clockwise carriageway of the M60 close to junction five.
Around this time a mini-cooper was travelling in the same direction and was involved in a collision with the pedestrian.
Despite the best efforts of paramedics; the pedestrian - a 45-year-old man - was pronounced dead at the scene.
No other injuries were reported and no arrests have been made.
Enquiries are ongoing.
Inspector Darren Hancock, Head of GMP's Serious Collision Investigation Unit said: "This was a tragic incident in which a man has very sadly lost his life. It's unclear at this stage as to why he had been walking along the motorway and this will form a part of the investigation carried out. We're following all available lines of enquiry to establish what exactly has occurred."
"We're appealing to anyone who may have been travelling on the road at the time and witnessed the collision or saw the man beforehand to get in touch with police as soon as possible. We're particularly keen to speak to anyone who may have dash-cam or video footage."
Anyone with information or footage should contact police on 0161 856 4741 quoting incident 2777 of 16/12/21. Alternatively, details can be passed via our LiveChat at www.gmp.police.uk or via the independent charity Crimestoppers on 0800 555 111.