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Police were called around 3.40am today (Wednesday 7 July 2021) by colleagues at NWAS requesting assistance at an address on Lake Road, Stalybridge.
Officers attended and enquiries established a woman in her 40s had been stabbed multiple times.
She was taken to hospital where she sadly pronounced dead a short while later.
A man in his 40s was later arrested in the Dukinfield area on suspicion of murder. He remains in custody for questioning.
Enquiries are ongoing.
Detective Superintendent Richard Hunt of GMP's Tameside district, said: "An investigation has been launched following the death of a woman this morning in Stalybridge and although our enquiries are in their early stages our main priority is ensuring her next of kin are identified and provided with the support they need.
"We are currently following all available lines of enquiry to ensure we piece together what has occurred this morning but I would encourage anyone with any information that could assist our enquiries to get in touch with police as a matter of urgency.
"Incidents such as this can be hugely unsettling for the community but I want to reassure the public that we are working at pace to ensure we establish the full circumstances and we currently have one man in custody. There will be an increased police presence in the area as our investigation continues and anyone with concerns or worries is encouraged to speak with officers in the area."
Anyone with information can contact police via LiveChat on our website www.gmp.police.uk or call 101 quoting incident number 342 of 07/07/21. Alternatively, contact Crimestoppers anonymously on 0800 555 111.