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Police were called just after 1am on Sunday 25 July to reports of a number of people presenting themselves at hospital with apparent gunshot wounds.
Four people attended hospital in total, one man aged 54 is being treated for serious injuries to his arm and another 48 year old man is in a serious condition and has undergone surgery.
A 27 year old woman and a 16 year old girl were also injured, it is unclear whether this is a result of a gunshot, debris from the discharge or from the disturbance at the scene.
The 16 year old has been discharged from hospital.
Following enquiries, It appears the group had been at an engagement party at an address on Birch Hall Lane in Longsight where a large amount of people had gathered. We believe at some point, shortly before 1am an altercation took place, possibly in the garden, and it's been reported five gun shots were fired. A scene is currently in place and officers are working to establish the circumstances of what has happened.
Shortly before 2am, police also received a report of a car on its roof on Thoresway Road, Longsight. It is uncertain whether this was connected to the shootings but detectives are exploring every line of inquiry, and out of caution are treating this as linked at this time.
Superintendent John Harris from the City of Manchester District said: "This kind of behaviour is completely unacceptable, and will not be tolerated.
"Our enquiries are still in the very early stages as we piece together what took place overnight, but we are currently at the scene and we are collating any evidence that can aid in our pursuit of who is responsible.
"We understand that this incident is worrying for the community, we have extra police patrols in place, and we will work to find out exactly what has happened, and bring those responsible to justice.
"As we piece together the details, if you live in the area, and heard anything last night then I urge you to contact us, as any information could really help at this stage."
Anyone with information can contact police via LiveChat on our website or call 0161 856 4409 quoting incident 248 of 25/07/2021. Details can also be passed anonymously to the independent charity Crimestoppers on 0800 555 111.