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At around 1.46am this morning (Wednesday 2 June 2021), police were called to a report of a road traffic collision involving a black Saab and a bicycle on Hyde Road, Gorton.
Emergency services attended and the cyclist - a 56-year-old man, was taken to hospital in a critical condition but has since sadly died.
The driver of the car, a 66-year-old man, was arrested at the scene on suspicion of causing death by dangerous driving and remains in custody.
Police Sergeant Matt Waggett, of GMP's Serious Collision Investigation Unit, said: "This is a tragic incident in which a man has very sadly lost his life and our thoughts are with his family during this extremely difficult time.
"We are working hard to piece together how the collision happened and we would urge anyone who witnessed this incident, or anyone who may have dashcam footage to get in touch as soon as possible."
Anyone with information should call GMP's Serious Collision Investigation Unit on 0161 856 4741 or 101 quoting incident number 219 of 02/06/2021, or the independent charity Crimestoppers, anonymously, on 0800 555 111.