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Police were called shortly after 5.05pm on Wednesday 26 May to a report of a disturbance involving a group of men at an address on Fifth Avenue, Oldham.
Emergency services attended and a man was sadly pronounced dead at the scene.
A bladed weapon was recovered close by and initial enquiries suggest the man was stabbed.
No arrests have been made and enquiries are ongoing.
Detective Chief Inspector Andy Butterworth, of GMP's Major Incident Team, said: "A shocking incident has occurred this evening and a man has lost his life in what appears to have been a targeted confrontation which resulted in the victim suffering fatal stab wounds.
"Our initial priority is supporting the man's family at this time and to work at great pace to find those responsible for this tragic act.
"Several lines of enquiry are already being explored and we ask anyone with information to support us in our endeavour to identify those involved and hold them responsible for their lethal actions tonight."
Anyone with information should contact police online, if able, via www.gmp.police.uk, or 101 quoting incident 2226 of 26/05/2021. Details can be passed anonymously to the independent charity Crimestoppers on 0800 555 111.