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Police were called around 5pm on Wednesday 16 February to Hamilton Street, Stalybridge to a report of a collision involving a Toyota Yaris and a bicycle.
Enquiries have since established the car and the cyclist had collided with one another in the centre of the junction of Hamilton Street and Cumberland Street.
The car then failed to remain at the scene.
The cyclist - a 10-year-old girl - was taken to hospital in a critical condition, where she currently remains.
Enquiries are ongoing and a 25-year-old man has since been arrested on suspicion of causing serious injury by dangerous driving.
Officers are appealing for anyone who may have witnessed the collision or were in the area at the time to get in touch with police.
They are particularly keen to speak to anyone who may have seen the Toyota Yaris in the area or has dash-cam footage from around the time of the collision.
Anyone with information should contact police on 0161 856 4741 quoting incident 2129 of 16/02/22.
Alternatively, details can be passed via our LiveChat function at www.gmp.police.uk or via the independent charity Crimestoppers on 0800 555 111.