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A 20-year-old man has been arrested on suspicion of murder. He remains in custody for questioning.
A murder investigation was launched on 9 September 2021 after officers were called to Norton Street in Trafford just before 6pm to a report of a stabbing.
Emergency services attended and found 16-year-old Rhamero West from South Manchester, with a number of stab wounds.
Emergency services provided vital medical treatment before he was taken to hospital where he sadly died a short time later.
A 16-year-old-boy who cannot be named for legal reasons, Xavier Wynter (08/06/03) of no fixed abode and Ryan Cashin (16/08/2002), of Nancy Street, Manchester, have already been charged with Rhamero's murder and have been remanded in custody to appear at a future date.
Detective Chief Inspector Liz Hopkinson, from GMP's Major Incident Team, said: "As always our thoughts remain with Rhamero's family as they process this incredibly difficult loss.
"This fourth arrests highlights the dedication and hard work of our officers who have been thoroughly investigating every single line of enquiry and gathering evidence in order to find answers for Rhamero's family and make sure those responsible face justice."