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At around 2am today (26.10.2022), officers out on patrol were flagged down to an incident on Wilmslow Road in Manchester.
Officers attended and established that one man had been seriously injured. They commenced CPR at the scene.
An investigation is underway.
Detective Superintendent Neil Jones of Greater Manchester Police South Manchester Division said: "I know that people in Manchester, and particularly those in the Fallowfield area will be shocked and concerned by this incident.
"I share this concern and assure you that there is a dedicated team of specialist officers in the area who are investigating at pace to find the person responsible.
"Local officers will be patrolling the areas and I urge anyone with information or concerns to speak to those officers who are on hand to help and support you."
Anyone with information should contact police via gmp.police.uk or 101 quoting 240 26/10/22. Information can be shared anonymously via the independent charity - Crimestoppers on 0800 555 111.