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The 14-year-old required hospital treatment after the incident on Fenchurch Avenue, Newton Heath, at around 5:30pm on Wednesday 17 May 2023.
The boy was treated at the scene by paramedics and been taken to hospital, where he remains in a stable condition.
Detective Inspector Paddy Connell, of GMP's City of Manchester North division, said: "The victim sustained life-changing injuries and remains in hospital following the incident.
"We have had an increased police presence in the area since the incident and are carrying out enquiries but we are still looking for information from the public to piece together what happened.
"Anyone with any information about this incident is urged to contact police on 0161 856 1146 quoting log 2802-15/05/23.
"Information can also be reported online or by using the LiveChat function at www.gmp.police.uk.
"If you can't report online, call 101 or Crimestoppers anonymously on 0800 555 111. Always call 999 in an emergency."
A 17-year-old male will appear in court today charged with section 18 wounding and possession of a bladed article.