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John McNamara, 42, was last seen on Gamble Street in Leigh, Wigan at around 4pm on Tuesday 16 March 2021.
He is described as being white, 6ft 1ins tall and of a slim build. He was last seen wearing dark clothing.
It is not known whether he has access to a phone or money.
John requires medication and officers are becoming increasingly concerned about him and want to make sure John is safe and well.
Anyone with any information about John's whereabouts should contact police on 0161 856 7253.